[Passive smoking during pregnancy and obstetric outcomes in pregnant women referring to Rafsanjan Nicknafs hospital]

Inhaling Environmental Tobacco Smoke [ETS], as a world health problem, threats the community especially mothers and newborns. The aim of this study was to determine the effects of passive tobacco smoking during pregnancy on mother and newborns. In this Cross sectional study, in one year, 641 non smoking women who refered to Rafsanjan Nicknafs hospital for bearing a singleton baby, were interviewed at least two hours after delivery using a structured check list. Based on history of exposure to ETS, the study samples were divided into two groups and then maternal and newborn outcomes in the two groups were compared. Exposure to ETS was reported among 25% [161] of respondents. The women exposed to ETS were less educated, multi gravid, had irregular prenatal care, older unemployed, lived in rural and in sum had low socio-economical status. They had higher rates of vaginal delivery [p=0.02], anemia [p=0.048] and preterm delivery [p=0.002]. But mother's exposure to ETS did not show any significant statistical relations with newborn weight, APGAR score, sex, anomaly and preeclampsia and the way of beginning the delivery Exposure to environmental tobacco smoke in pregnancy probably increases the risk of preterm labor and maternal anemia

[ effects of CCK-8 and CCK2 receptor antagonists on naloxone-induced jumping in morphine dependent mice]

Opioids are an important group of analgesics that are used extensively to control sever pains. Physical dependence to these drugs is a major problem. There are a few studies regarding the involvement of cholecyctokinin [CCK] in the withdrawal syndromes of opioids. In the present study, the effects of CCK agonist and antagonist on the number of jumping of morphine dependent mice were evaluated. In this experimental study, the effects of CCK-8 and LY225910 [selective CCK2 receptor antagonist] on jumpings of mice after morphine dependence were evaluated. Mice were injected with morphine three times a day [50, 50 and 75 mg/kg] for three days; at the forth day they received 50 mg/kg morphine. Injection of naloxone [5 mg/kg] induced withdrawal signs such as jumping. The experimental groups received different doses of CCK-8 [0.1, 0.3 and 0.6 mg/kg] and LY225910 [0.01, 0.5 and 1 mg/kg] with each injection of morphine. Injection of CCK-8 significantly decreased the naloxone-induced jumpings, while LY225910 did not have any significant effects on these jumpings. Based on the results of the present study, activation of CCK1 receptors probably is involved in morphine dependence. The results also confirm that injection of CCK but not CCK2 selective antagonist probably decreases the jumpings of mice following withdrawal syndrome of morphine